Fig. 2.

Expression profiles of genes encoding DRM-associated proteins. Data from RNA sequencing of P. falciparum blood stages (20), available in PlasmoDB, were used to determine the expression profiles of genes encoding DRM-associated proteins at different time points of parasite development: ring (R), early trophozoite (ET), late trophozoite (LT), schizont (S), and early (GII) and late (GV) gametocytes. Blue and yellow boxes correspond to positive and negative values, respectively, and zero is shown as a white box. Six clusters were identified by the self-organizing tree clustering algorithm. For each cluster, a centroid profile is shown (left) in which red bars represent the standard deviations at each time point. Pie charts represent the functional classification of proteins in each cluster.