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. 2013 Dec 13;7:199. doi: 10.3389/fnbeh.2013.00199

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Copyright © 2013 Orsini, Yan and Maren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Freezing behavior in extinguished and non-extinguished rats during the test sessions. Rats were fear conditioned in Context A on Day 1 and subsequently underwent context exposure and extinction in Context C and Context B (contexts were counterbalanced) on Day 2. During the retrieval test on Day 3, rats were tested twice: once in the extinction context and once outside the extinction context, with each test separated by an 18-min interval. Each test consisted of three tone-alone presentations with 30 s ISIs. Immediately after the second test, rats were sacrificed and brains were extracted for catFISH processing. Freezing behavior during conditioning and extinction was typical and did not differ from previous reports (Orsini et al., 2011); thus, it is not displayed. (A) Mean percentage of freezing (±SEM) to the CS when presented within the extinction context (“Same”). Freezing was measured during the baseline (BL) period (two 1-min blocks), during three 40-s trials, each of which consisted of a 10-s CS presentation and the subsequent 30-s ISI, and during the post-tone period (Post) (three 1-min blocks). (B) Mean percentage of freezing (±SEM) to the CS when presented outside of the extinction context (“Different”). Freezing was measured during the baseline (BL) period (two 1-min blocks), during three 40-s trials, each of which consisted of a 10-s CS presentation and the subsequent 30-s ISI, and during the post-tone period (Post) (three 1-min blocks). (C) Mean percentage of freezing (±SEM) during the test trials for extinguished (EXT) and non-extinguished (NO-EXT) rats. For all figures, freezing was collapsed across Same/Diff and Diff/Same groups to yield an overall mean percentage of freezing (±SEM) for the renewal and extinction test.