TABLE 1.
Effects of FO on fasting plasma lipid and lipoprotein concentrations in rhesus monkeys fed a high-fructose diet1
| Control (n = 9) |
FO (n = 10) |
|||
| Result | Δ | Result | Δ | |
| mg/dL | mg/dL | |||
| Cholesterol | ||||
| Baseline | 142 ± 8 | — | 137 ± 9 | — |
| 6 mo | 146 ± 8 | +5 ± 4 | 125 ± 10 | −12 ± 6 |
| LDL-C | ||||
| Baseline | 70 ± 6 | — | 66 ± 7 | — |
| 6 mo | 64 ± 5 | −6 ± 4 | 62 ± 7 | −5 ± 5 |
| HDL-C | ||||
| Baseline | 55 ± 3 | — | 54 ± 4 | — |
| 6 mo | 55 ± 4 | 0 ± 3 | 49 ± 5 | −5 ± 2* |
| TGs | ||||
| Baseline | 83 ± 8 | — | 81 ± 10 | — |
| 6 mo | 136 ± 22 | +53 ± 21* | 74 ± 8 | −7 ± 7‡ |
| ApoA1 | ||||
| Baseline | 143 ± 6 | — | 144 ± 4 | — |
| 6 mo | 147 ± 8 | +4 ± 4 | 132 ± 6 | −11 ± 3† |
| ApoB | ||||
| Baseline | 55 ± 4 | — | 51 ± 5 | — |
| 6 mo | 56 ± 4 | +1 ± 3 | 50 ± 6 | −1 ± 3 |
| ApoC3 | ||||
| Baseline | 2.28 ± 0.19 | — | 2.28 ± 0.19 | — |
| 6 mo | 2.85 ± 0.19 | +0.57 ± 0.13** | 2.11 ± 0.21 | −0.17 ± 0.18‡ |
| ApoE | ||||
| Baseline | 2.12 ± 0.15 | — | 1.92 ± 0.13 | — |
| 6 mo | 2.74 ± 0.14 | +0.62 ± 0.14* | 2.09 ± 0.14 | +0.18 ± 0.11† |
1
Values are means ± SEMs. Differences in means from baseline: *P ≤ 0.05, **P ≤ 0.01. Differences in means from baseline to 6 mo between control and FO groups: †P ≤ 0.05, ‡P ≤ 0.01. FO, fish oil; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol.