Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Sep;14(6):361–370. doi: 10.2174/1389202911314060009

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

©2013 Bentham Science Publishers

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. (10) — Regulation of the Excitatory/Inhibitory balance by Otx2 transfer. A. Otx2 binds PNNs through its GAG-binding domain (RK domain) and is internalized by PV-cells. Before CP opening or during CP, this internalization drives PV-cell maturation and enhances its inhibition strength upon Pyramidal cells, inducing a shift in the excitatory/inhibitory (E/I) balance. Infusing the RK peptide (the Otx2 PNN-binding domain) decreases Otx2 internalization and reopens a period of plasticity. B. According to this 2 threshold model, the accumulation of Otx2 (green arrow) opens at P20 (threshold 1) and closes at P40 (threshold 2) a critical period for plasticity. The permanent transfer of Otx2 maintains plasticity in a closed state throughout adulthood. Infusing the RK-peptide (A) blocks Otx2 internalization in the adult and reopens a period of plasticity (red arrow).