Table 2.
Diagnostic core biopsy and surgical specimen mean percent levels (±standard error of mean) of Ki-67, caspase-3, and CD34 in benign and malignant cell components in green tea and control group.
| Ki-67 | Green tea (n = 10) | Control (n = 12) | P valuec | P valued | |
|---|---|---|---|---|---|
| Benign cells | Biopsy | 5.95 ± 1.30 | 3.05 ± 0.74 | 0.057 | 0.075 |
| Surgical | 2.81 ± 0.81 | 2.30 ± 0.57 | 0.61 | 0.60 | |
| Change | −3.14 ± 0.91 | −0.75 ± 0.58 | 0.033 | 0.075 | |
| P valuea,b | 0.007/0.11 | 0.22/0.21 | |||
| Green tea (n = 12) | Control (n = 12) | ||||
| Malignant cells | Biopsy | 27.47 ± 3.31 | 18.13 ± 5.39 | 0.15 | 0.04 |
| Surgical | 23.18 ± 4.31 | 18.81 ± 6.41 | 0.58 | 0.30 | |
| Change | −4.29 ± 2.42 | 0.68 ± 6.02 | 0.45 | 0.95 | |
| P valuea,b | 0.10/0.14 | 0.91/0.18 | |||
| Cleaved caspase-3 | Green tea (n = 8) | Control (n = 9) | P valuec | P valued | |
| Benign cells | Biopsy | 5.72 ± 1.65 | 10.86 ± 3.31 | 0.20 | 0.47 |
| Surgical | 6.79 ± 1.81 | 9.69 ± 4.82 | 0.60 | 0.92 | |
| Change | 1.07 ± 2.87 | −1.17 ± 4.81 | 0.70 | 0.53 | |
| P valuea,b | 0.72/0.51 | 0.81/1.00 | |||
| Green tea (n = 11) | Control (n = 11) | ||||
| Malignant cells | Biopsy | 13.16 ± 3.47 | 14.22 ± 6.01 | 0.88 | 0.45 |
| Surgical | 14.57 ± 7.42 | 13.20 ± 6.42 | 0.89 | 0.90 | |
| Change | 1.41 ± 6.40 | −1.02 ± 1.78 | 0.72 | 0.89 | |
| P valuea,b | 0.83/0.63 | 0.58/0.63 | |||
| CD34 (#vessels/tissue area) | Green tea (n = 7) | Control (n = 10) | P valuec | P valued | |
| Benign cells | Biopsy | 0.83 ± 0.29 | 1.85 ± 0.43 | 0.09 | 0.12 |
| Surgical | 0.32 ± 0.07 | 1.36 ± 0.42 | 0.058 | 0.12 | |
| Change | −0.51 ± 0.28 | −0.49 ± 0.37 | 0.97 | 0.70 | |
| P valuea,b | 0.12/0.13 | 0.22/0.24 | |||
| Green tea (n = 9) | Controls (n = 12) | ||||
| Malignant cells | Biopsy | 0.18 ± 0.08 | 0.45 ± 0.16 | 0.18 | 0.62 |
| Surgical | 0.13 ± 0.08 | 0.48 ± 0.21 | 0.18 | 0.39 | |
| Change | −0.05 ± 0.11 | 0.03 ± 0.18 | 0.74 | 0.83 | |
| P valuea,b | 0.66/0.11 | 0.88/0.24 | |||
aP value for changes between biopsy core and surgical specimen samples for benign or malignant cells separately for green tea and control groups using paired t-test.
bP value for changes between biopsy core and surgical specimen samples for benign or malignant cells separately for green tea and control groups using signed rank test.
cP value for differences between levels in green tea and control groups using t-test.
dP value for differences between levels in green tea and control groups using ranksum test.