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. 2013 Jul 9;20(e2):e243–e252. doi: 10.1136/amiajnl-2013-001930

Figure 4.

Figure 4

Two implementations of the same electronic health record phenotyping algorithm. Step 1 is implemented the same for both approaches. Step 2 differs by the query anchor and the time frame for which laboratory values are checked to be within normal ranges. The top implementation is anchored on the date of medication administration with laboratory values checked within 30 days before. The bottom implementation is anchored on the date of acute liver injury diagnosis with laboratory values checked between 180 and 90 days before. Step 3 differs by the query anchor and the time frame for which laboratory values are checked for thresholds to qualify as drug-induced liver injury (DILI). The top implementation is anchored on the date of medication administration with laboratory values checked within 180 days following drug administration. The bottom implementation is anchored on the date of acute liver injury diagnosis with laboratory values checked within 90 days before. CU, Columbia University; Mayo, Mayo Clinic; MSSM, Mount Sinai School of Medicine.