Table 2.

DILI EHR phenotyping algorithm adaptations

Agreed-upon specifications	CU	Mayo	MSSM
Medication order temporal relationship ▸ Medication order within 90 days prior to acute liver injury diagnosis	Agreed-upon specs	Agreed-upon specs with common medications implicated in DILI cases	Agreed-upon specs with ANY medication
Laboratory value temporal relationship ▸ Laboratory values crossing threshold for DILI within 90 days of acute liver injury diagnosis. ▸ All laboratory values below ULN within 30 days before medication administration	Agreed-upon specs	Agreed-upon specs	Agreed-upon specs
Laboratory value thresholds	iSAEC specified	Manufacturer specified	Manufacturer specified
Excluded diagnoses ▸ Chronic liver injury, sclerosing cholangitis, organ transplantation or liver operation, alcohol abuse/liver damage/toxic effects, viral hepatitis, death, overdose	Agreed-upon specs	Only excluded chronic liver injury cases	Only excluded chronic liver injury cases

CU, Columbia University; DILI, drug-induced liver injury; EHR, electronic health record; iSAEC, International Serious Events Consortium; Mayo, Mayo Clinic; MSSM, Mount Sinai School of Medicine; ULN, upper limit of normal.