Table 2.
Exposure or outcome | HA-CDI cases (n=362) | HA-CDI controls (n=362) | p Value | HR or OR (95% CI) |
---|---|---|---|---|
Length of stay, median (IQR), days | 20 (13–33) | 9 (6–14) | <0.001 | 0.34 (0.30 to 0.41)* |
<0.001 | 0.33 (0.28 to 0.39)† | |||
30-Day post-discharge mortality, no. (%) | 80 (22) | 42 (12) | 0.05 | 1.48 (1.00 to 2.17)* |
0.10 | 1.38 (0.94 to 2.04)† | |||
High-risk antibacterial exposure, no. (%)‡,§ | 240 (66) | 124 (34) | <0.001 | 3.77 (2.74 to 5.20)¶ |
Low-risk antibacterial exposure, no. (%)‡,§ | 249 (69) | 168 (46) | <0.001 | 2.54 (1.86 to 3.49)¶ |
PPI or H2-blocker exposure, no. (%)‡,§ | 297 (82) | 265 (73) | 0.006 | 1.67 (1.16 to 2.43)¶ |
*Unadjusted HR.
†Adjusted HR.
‡Medication POE data collected up to 24 h before diagnosis for cases, and for the first 48 h of healthcare exposure, for controls.
§Aggregate medication categories are defined in supplementary Table S2 (available online only).
¶OR.
HA-CDI, hospital-acquired C difficile; POE, provider order entry.