Table 2.
Univariate Analysis of Event-Free and Overall Survival
| Variable | n | Event-free survival | Overall survival | ||
|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | ||
| ALC (continuous) | 399 | 1.00 (1.00, 1.00) | .092 | 1.00 (1.00, 1.00) | .029 |
| ALC (< 500 cells/μl vs. ≥ 500 cells/μl) | 34 vs. 365 | 2.10 (0.99, 4.46) | .053 | 2.82 (1.15, 6.91) | .023 |
| Age at diagnosis (1–9 vs. ≥ 10 years) | 295 vs. 107 | 0.46 (0.26, 0.79) | .005 | 0.22 (0.11, 0.46) | <.001 |
| Leukocyte count at diagnosis (continuous) | 402 | 1.00 (1.00, 1.00) | .040 | 1.00 (1.00, 1.00) | .826 |
| Leukocyte count at diagnosis (< 50 vs. ≥ 50 × 103/μL) | 295 vs. 107 | 0.68 (0.38, 1.19) | .175 | 0.71 (0.33, 1.52) | .375 |
| Leukocyte count at end of induction (continuous) | 397 | 0.96 (0.83, 1.12) | .605 | 1.04 (0.94, 1.15) | .447 |
| ANC at end of induction (continuous) | 396 | 1.00 (1.00, 1.00) | .519 | 1.00 (1.00, 1.00) | .024 |
| Platelets at end of induction (continuous) | 398 | 1.00 (1.00, 1.00) | .354 | 1.00 (1.00, 1.00) | .270 |
| MRD (Negative vs. Positive) | 321 vs. 77 | 0.223 (0.13, 0.39) | < .001 | 0.17 (0.08, 0.35) | <.001 |
| Lineage (B vs. T) | 339 vs. 63 | 0.39 (0.22, 0.70) | .002 | 0.42 (0.19, 0.92) | .029 |
| Initial risk group (low vs. standard/high) | 225 vs. 177 | 0.25 (0.14, 0.46) | < .001 | 0.27 (0.12, 0.61) | .001 |
ALC, absolute lymphocyte count; ANC, absolute neutrophil count; MRD, minimal residual disease