Table 3.
Multivariable Cox Proportional Regression Model (ALC as a categorical variable)
Variable | Event-free survival | Overall survival | ||
---|---|---|---|---|
Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | |
ALC (< 500 cells/μl vs. ≥ 500 cells/μl) | 1.04 (.44, 2.42) | .930 | 1.62 (.57, 4.56) | .362 |
Age at diagnosis (1 to 9 vs. ≥ 10 years) | .90 (.49, 1.66) | .736 | .30 (.13, .70) | .005 |
Leukocyte count at diagnosis (< 50 vs. ≥ 50 × 103/μL) | 1.39 (.71, 2.70) | .334 | 1.00 (.41, 2.50) | .996 |
Lineage (B vs. T) | .80 (.39, 1.65) | .548 | .90 (.33, 2.45) | .836 |
Initial risk group (low vs. standard/high) | .30 (.14, .66) | .003 | .70 (.24, 2.01) | .505 |
MRD (Negative vs. Positive) | .30 (.17, .53) | < .001 | .22 (.10, .46) | < .001 |
ALC, absolute lymphocyte count; MRD, minimal residual disease