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. 2013 Dec 13;7:238. doi: 10.3389/fnins.2013.00238

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Copyright © 2013 Anwar and Derbenev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPV1 antagonist prevents the potentiation of excitatory neurotransmission caused by TRPV1 activation to DMV neurons. (A) Continuous recording of mEPSCs in the presence of 5′-iRFT (1μM) and TTX (1μM) at 25°C (A) and after increase of temperature from 25°C to 37°C (A₁). (B,C). The effect of TRPV1 antagonist on the increase of mEPSC frequency (B) and amplitude (C). (D–F). Summary for temperature response on mEPSC frequency (D), mEPSC amplitude (E), and total inward current (F) (n = 6). Black traces indicate control conditions. Red traces indicate recordings conducted in the presence of 5'-iRFT, a TRPV1 antagonist. Dashed-line indicates physiological temperature. ^*Significance (p < 0.05).