Figure 4.

TRPV1 antagonist prevents the increase of inhibitory neurotransmission to DMV neurons caused by TRPV1 activation. (A). Continuous recording of mIPSCs in the presence of 5′-iRFT (1 μM) and TTX (1 μM) at 25°C (A) and after rise of temperature from 25 to 37°C (A₁). (B,C). The effect of TRPV1 antagonist on the increase of mIPSC frequency (B) and amplitude (C) (red traces are recordings with 5′-iRFT). (D–F). Summary for temperature response on mIPSC frequency (D), mIPSC amplitude (E), and total outward current (F) (n = 7). Black traces indicate control conditions. Red traces indicate recordings conducted in the presence of 5′-iRFT, a TRPV1 antagonist. Dashed-line indicates physiological temperature. ^*Significance (p < 0.05).