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. Author manuscript; available in PMC: 2013 Dec 13.
Published in final edited form as: J Med Chem. 2007 Aug 16;50(18):10.1021/jm070284z. doi: 10.1021/jm070284z

Scheme 4.

Scheme 4

Synthesis of Symmetrically Acylated Protease Inhibitorsa

a Reagents and conditions: (a) i-PrOH, 80 °C, 24 h; (b) 4 N HCl–dioxane, 50 °C, 4 h; (c) acid 11a or 11e, (COCl)2, rt, overnight; (d) Et3N, THF, 0 °C to rt, 8 h.