Table 5.

Hydrogen-Bonding Distances between Protease and Inhibitor Atoms in Crystal Structures of LPV, 13e, and 14a

protease atom	inhibitor atom	distance (Å) for
		LPV	13e	14a
Asp 29 N	O30		2.8
Asp 29 OD1	O30		3.2
Asp 29 OD2	O30		3.5
water	O30		3.3 (W69)a
water	O30		3.1 (W12)	3.3 (W23)
Asp 30 N	O30			3.0
water	N31			3.3 (W23)
water	O28		2.9 (W69)	3.5 (W23)
Gly 27 O	N4		3.3
water	O5	2.6 (W36)	2.7 (W6)	2.7 (W6)
Asp 25 OD1	O4	3.0	2.7	2.8
Asp 25 OD2	O4	2.8	2.8	2.7
Asp 25′ OD1	O4	2.7	3.0	2.8
Asp 25′ OD2	O4	2.7	2.6	3.0
Gly 27′ O	N3	3.0	3.0	3.0
water	O2	2.6 (W36)	2.7 (W6)	2.7 (W6)
water	O1	3.2 (W26)	3.2 (W67)	3.1 (W3)
Asp 29′ N	O1	2.7	2.9	2.8
Asp 29′ OD2	N2	3.0		3.1
Arg 8 NH2	N2	3.5
Gly 48′ O	N1		3.1

^aThe corresponding water number is in parentheses.