Table 6.
Results of LHS sensitivity analysis of the parameters in Table 5. For each strategic treatment interruption (abbreviated as STI above) plan, 500 simulations are performed in which every parameter is randomly varied over the ranges given in Table 5. We report the fraction of LHS samples that result in a successful treatment. A success is defined as a simulation in which the total cancer population falls below 10−10k/μL
Treatment plan: STI days | Fraction of successful treatments | Treatment plan: plan: STI days | Fraction of successful treatments |
---|---|---|---|
90 ≤ t ≤ 105 | 0.488 | 120 ≤ t ≤ 135 | 0.544 |
150 ≤ t ≤ 165 | 0.568 | 180 ≤ t ≤ 195 | 0.450 |
210 ≤ t ≤ 225 | 0.544 | 240 ≤ t ≤ 255 | 0.546 |
270 ≤ t ≤ 285 | 0.468 | 300 ≤ t ≤ 315 | 0.650 |
330 ≤ t ≤ 345 | 0.512 | 360 ≤ t ≤ 375 | 0.486 |
390 ≤ t ≤ 405 | 0.474 | 90 ≤ t ≤ 120 | 0.434 |
120 ≤ t ≤ 150 | 0.458 | 150 ≤ t ≤ 180 | 0.480 |
180 ≤ t ≤ 210 | 0.516 | 210 ≤ t ≤ 240 | 0.542 |
240 ≤ t ≤ 270 | 0.566 | 270 ≤ t ≤ 300 | 0.588 |
300 ≤ t ≤ 330 | 0.624 | 330 ≤ t ≤ 360 | 0.578 |
360 ≤ t ≤ 390 | 0.550 | 390 ≤ t ≤ 420 | 0.542 |
90 ≤ t ≤ 135 | 0.450 | 150 ≤ t ≤ 195 | 0.524 |
210 ≤ t ≤ 255 | 0.578 | 270 ≤ t ≤ 315 | 0.624 |
330 ≤ t ≤ 375 | 0.528 | 390 ≤ t ≤ 435 | 0.536 |
450 ≤ t ≤ 495 | 0.530 | 510 ≤ t ≤ 555 | 0.544 |
570 ≤ t ≤ 615 | 0.528 | 630 ≤ t ≤ 675 | 0.526 |
690 ≤ t ≤ 735 | 0.518 | 750 ≤ t ≤ 795 | 0.494 |