Table 2.
Substrate scope under the optimized reaction conditions.
| ||||
|---|---|---|---|---|
| entry | 7 | 8 | 8:9 | % conversiona (isolated yield) |
| 1 |
 7a |
 8a |
>20:1 | >95 (81%) |
| 2 |
 7b |
 8b |
>20:1 | >95 (90%) |
| 3 |
 7c |
 8c |
>20:1 | >95 (50%) |
| 4 |
 7d |
 8d |
10:1 | 85 (45%)b |
| 5 |
 7e |
 8e |
8:1 | 70 (39%)b |
| 6 |
 7f |
 8f |
4:1 | 90 (43%)b |
| 7 |
 7g |
 8g |
>20:1 | 85 (66%) |
| 8 |
 7h |
 8h |
>20:1 | 50 (28%) |
| 9 |
 7i |
 8i |
>20:1 | 95 (82%) |
| 10 |
 7j |
 8j |
>20:1 | 50 (24%) |
| 11 |
 7k |
 8k |
>20:1 | 90 (76%) |
| 12 |
 7l |
 8l |
>20:1 | 80 (65%) |
a
The reaction conversion and ratio of 8:9 was determined based on the 1H NMR of the crude reaction mixture.
b
Isolated yield as an inseparable mixture of isomers.