Table 2.

Strain-specific VE in several host-genetics subgroups in the RV144 trial

SNP	Genotype	VE (%)	95% CI	p-value†	p-value‡	Adjusted p-value§
169 match virus strain
Fc-γR2b/rs145835719	CC	32.50	(−9.98, 58.57)	0.1146	—	—
	CA/AA	82.35	(39.78, 94.83)	0.0056	0.0465	0.5826
Fc-γR2c/rs138747765	CC	15.15	(−40.40, 48.72)	0.5225	—	—
	CT/TT	90.91	(61.34, 97.86)	0.0012	0.0043	0.0414
Fc-γR3a/rs147342954	GG	60.98	(30.46, 78.1)	0.0014	—	—
	GA/AA	12.50	(−79.28,57.29)	0.7152	0.0857	0.8186
181 mismatch virus strain
Fc-γR2b/rs145835719	CC	66.67	(−3.35, 89.25)	0.0571	—	—
	CA/AA	100	(−100,100)	0.9944	0.9948	1
Fc-γR2c/rs138747765	CC	69.23	(5.63, 89.97)	0.0393	—	—
	CT/TT	100	(−100,100)	0.9961	0.9963	1
Fc-γR3a/rs147342954	GG	84.62	(31.82, 96.53)	0.0137	—	—
	GA/AA	50	(−100,90.84)	0.4235	0.3062	0.9999

^†p-value assessing the significance of strain-specific VE within a genetic subgroup.

^‡p-value comparing strain-specific VE between two genetic subgroups.

^§p-value adjusting for the family-wise error rate.