Table 1.
GWAS | No. of associated SNPs | HMR | Cell-type–specific HMR* | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CD4 | CD8 | CD14 | CD16 | CD19 | PBMC | CD4 | CD8 | CD14 | CD16 | CD19 | ||
Crohn's disease | 70 | 30† | 30† | 33† | 32† | 29† | 28† | 12 (1)† | 9 (2)† | 10† | 11† | 12 (1)† |
Primary biliary cirrhosis | 20 | 10† | 10† | 11† | 11† | 10† | 9 | 2† | 2† | 4† | 2 | 3 |
T1D | 64 | 25† | 24† | 23† | 24† | 24† | 22† | 6 (2)† | 2 | 6 (1) | 6 (1) | 5 |
Ulcerative colitis | 45 | 16 | 15 | 17 | 16 | 16 | 14 | 4 | 4 (1) | 3 | 5 (1) | 4 |
HMRs that specifically occur in the given cell type (see “Methods”); values in parentheses indicate number of SNPs within the subset rHMRs (i.e., those associated with a change in gene expression).
P < .0001.