Table 1.
Antimicrobial activity spectrum of synthetic rondonin compared to gomesin. The minimal inhibitory concentrations (MICs) of the synthetic peptides were determined by liquid growth inhibition. MICs are expressed as the (a) and (b) interval of concentrations where (a) is the highest concentration tested at which the microorganisms are growing and (b) is the lowest concentration that causes 100% growth inhibition.
| Minimal inhibitory concentration (μM) |
||||||
|---|---|---|---|---|---|---|
| Microorganisms | Rondonin | Gomesin | ||||
| Gram-positive bacteria | ||||||
| Micrococcus luteus A270 | ND | 0.4 | – | 0.8a | ||
| Staphylococcus aureus ATCC 29213 | ND | 1.2 | – | 2.5b | ||
| Staphylococcus epidermides ATCC 12228 | ND | NA | ||||
| Gram-negative bacteria | ||||||
| Escherichia coli SBS363 | ND | 0.4 | – | 0.8a | ||
| Escherichia coli ATCC 25922 | ND | 0.2 | – | 0.9b | ||
| Pseudomonas aeruginosa ATCC 27853 (Strain Boston 41501) | ND | NA | ||||
| Fungi | ||||||
| Beauveria bassiana | ND | NA | ||||
| Trichosporon sp IOC 4569 | 1.1 | – | 2.1 | 0.6 | – | 1.2b |
| Yeasts | ||||||
| Candida albicans MDM8 | 16.75 | – | 33.5 | 0.15 | – | 0.3a |
| Candida krusei IOC 4559 | 16.75 | – | 33.5 | 5.0 | – | 10.0b |
| Candida glabrata IOC 4565 | 8.37 | – | 16.5 | 12.5 | – | 25 |
| Candida albicans IOC 4558 | 8.37 | – | 16.5 | 5.0 | – | 10.0b |
| Candida parapsilosis IOC 4564 | 16.75 | – | 33.5 | 2.5 | – | 5.0b |
| Candida tropicalis IOC 4560 | 8.75 | – | 16.5 | 0.3 | – | 0.6b |
| Candida guilliermondii IOC 4557 | 16.75 | – | 33.5 | 2.5 | – | 5.0b |