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. 2013 Aug 12;3:135–142. doi: 10.1016/j.ijpddr.2013.07.001

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© 2013 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Fig. 3 — IC₅₀ (nM) comparisons between mutant and wild type alleles at codons 51, 59, and 108 in dhfr and comparison between parasites with wild type versus dhfr N51I/C59R/S108N triple mutation and dhfr N51I/C59R/S108N and dhps A437G quadruple mutation. (a) We found significant increases in the geometric mean IC₅₀ values for ex vivo pyrimethamine susceptibility between mutant and wild type alleles (Mann–Whitney U test, p = 0.0001). Pyrimethamine IC₅₀s were measured ex vivo in 2011 using the DAPI drug assay. (b) IC₅₀s were different between wild type and dhfr N51I/C59R/S108N triple mutation parasites, as well as between wild type and dhfr N51I/C59R/S108N and dhps A437G quadruple mutation parasites (Mann–Whitney U test, p = 0.0002 for both comparisons).