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Ex vivo pyrimethamine IC50 values for resistant and sensitive isolates.
| Isolates tested | Pyrimethamine sensitive isolates (n = 10) | Pyrimethamine resistant isolates (n = 56) | (Mann–Whitney U test) p-value |
|---|---|---|---|
| Field isolates (n = 66) median (lowest–highest) IC50 (nM) | 15.5 (2.4–1503) | 15,725 (2259–201,046) | 0.0001 |
| 3D7 | 47.2 | – | |
| Dd2 | – | 49,464 |
