Fig. 2.

Information diagram showing the basic concept of searching for drug targets for use in malarial therapy and a new SL therapy for the elimination of antimalarial drug-resistant Plasmodium. Information diagram of the basic concept of a drug target search for malarial therapy. In this study, the phylogenetic inference of synthetic lethal (SL) genes extracted from yeast and malaria parasites was utilized for pharmacologic purposes because most existing SL data are restricted to yeast screenings. SL pairs with human orthologs were not considered.