Fig. 3.

Schematic diagram of the synthetic lethal (SL) gene identification methodology. Biological information from different databases including BioGRID, KEGG, and PlasmoDB were integrated. To search for potential antimalarial drug targets, the inferred Plasmodium SL gene network was reconstructed by phylogenetic analysis and database manipulation. The databases employed in this study were BioGRID for yeast SL genes, as well as KEGG and PlasmoDB for Plasmodium genes.