Table 1.
EC50 (effective concentration for 50% inhibition) with 95% confidence limits (CL) in nM and the resistance ratios (RR) for the tested macrocyclic lactones in the LDA for susceptible and resistant isolates of Haemonchus contortus (H.c. McM, H.c. CAVR), Trichostrongylus colubriformis (T.c. McM, T.c. MOX-R) and Ostertagia circumcincta (O.c. McM, O.c. WAMIRO).
| Drugs | H.c. McM | H.c. CAVR | RR | p | T.c. McM | T.c. MOX-R | RR | p | O.c. McM | O.c. WAMIRO | RR | p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EC50 (CL) | EC50 (CL) | EC50 (CL) | EC50 (CL) | EC50 (CL) | EC50 (CL) | |||||||
| B1a | 0.913 (0.75–1.11) | 2.83 (2.42–3.31) | 3.10 | ⁎ | 3.54 (3.09–4.04) | 56.1 (47.42–66.31) | 15.85 | ⁎ | 3.59 (3.47–4.23) | 15.1 (10.31–22.23) | 4.21 | ⁎ |
| B1b | 0.996 (0.73–1.36) | 3.35 (3.01–3.73) | 3.38 | ⁎ | 6.76 (6.25–7.31) | 82.5 (64.14–106.1) | 12.20 | ⁎ | 3.62 (2.92–4.49) | 8.96 (7.577–10.59) | 2.48 | ⁎ |
| IVM | 0.635 (0.49–0.83) | 4.21 (3.74–4.73) | 6.63 | ⁎ | 5.57 (4.99–6.22) | 52.5 (44.64–61.64) | 9.43 | ⁎ | 5.58 (5.06–6.16) | 14.3 (10.87–18.85) | 2.56 | ⁎ |
| MOX | 0.965 (0.62–1.49) | 2.33 (2.07–2.62) | 2.42 | ⁎ | 7.00 (5.70–8.59) | 50.8 (41.81–61.60) | 7.26 | ⁎ | 5.04 (4.69–5.40) | 5.71 (4.67–6.99) | 1.13 | |
| Mil A3 | 0.752 (0.68–0.83) | 6.50 (5.96–7.10) | 8.64 | ⁎ | 8.45 (5.94–12.02) | 271 (215.9–339.4) | 32.07 | ⁎ | 3.56 (2.71–4.68) | 14.7 (12.68–16.3) | 4.13 | ⁎ |
| Mil A4 | 0.364 (0.34–0.39) | 3.40 (3.00–3.85) | 9.34 | ⁎ | 4.25 (3.58–5.06) | 123 (108.4–139.4) | 28.94 | ⁎ | 1.77 (1.33–2.36) | 7.09 (5.54–9.07) | 4.01 | ⁎ |
⁎
p < 0.0001.