Table 2.
Neuropeptide-like G protein-coupled receptors (GPCRs) that following knockout or RNA interference induce deleterious phenotype in Caenorhabditis elegans.
| GPCR | Most potent ligand | Aberrant phenotypes reported |
|---|---|---|
| Y58G8A.4 (FLP18R2) | FLP-181 | Sterile, lethal |
| C54A12.2 | Embryonic lethal2 | |
| AC7.1/TAG-49 | Embryonic lethal, sick, maternal sterile3,4 | |
| T23B3.4 (CKR-1) | Embryonic lethal, reduced life span, reduced brood size5,6 | |
| C30F12.6 (NMUR-4) | Larval arrest, sterile, embryonic lethal7 | |
| C10C6.2 (NPR-3/FLP-15R) | FLP-158 | Some paralysis, locomotion variant, reduced brood size, sluggish9 |
| F59D12.1 | Paralysed, locomotion variant, sluggish, flat locomotion path, frequency body bend reduced9 | |
| Y54E2A.1 | Locomotion variant, maternal sterile5,6 | |
| T05A1.1 (NPR-2) | Locomotion variant, locomotion reduced, kinker9 | |
| T02E9.1 | Locomotion variant, sluggish, body bend reduced9 | |
| C04E6.9 (SRD-16) | Locomotion variant10 | |
| C16D6.2 (FLP18R1) | Reduced fertility, fewer egg-laying events during active9 | |
| Y59H11AL.1 (VRFaR2) | FLP-711 | Reduced brood size7 |
| T22D1.12 (NPR-12) | Reduced brood size5 | |
| F41E7.3 | Fewer egg-laying events during active9 | |
| C25G6.5 (NPR-11/FLP-21R) | FLP-2112 | Fewer egg laying events during active |
| F21C10.12 | Egg laying defective13 | |
| F54D7.3 (GnRHR) | NLP-4714 | Delayed egg laying14 |
| Y39A3B.5 (CKR-2) | NLP-1215 | Reduced life span6 |
| T27D1.3 (NPR-15) | Organism development variant16 | |
| C26F1.6 (VRFaR1) | FLP-717 | Hyperactive egg laying9 |
| F35G8.1 | Hyperactive egg laying9 |
Deleterious refers to lethality, reduced lifespan, or aberrant motility or reproduction. Where known, most potent ligand is indicated. Note that most of these GPCRs have orthologues in D. melanogaster, but (with the exception of F54D7.3) all are listed on FlyBase as ‘no phenotypic data available’ (http://www.flybase.org; FB2011_07, 21/07/2011). Phenotype data from WormBase (http://www.wormbase.org; WS225 16/06/2011), or as referenced: 1Kubiak et al. (2008), 2Sonnichsen et al. (2005), 3Kamath et al. (2003), 4Simmer et al. (2003), 5Rual et al. (2004), 6Park et al. (2010), 7Ceron et al. (2007), 8Kubiak et al. (2003), 9Keating et al. (2003), 10Zugasti et al. (2005), 11Mertens et al. (2006), 12Lowery et al. (2003), 13Gort et al. (2008), 14Lindemans et al. (2009), 15Janssen et al. (2008), 16Byrne et al. (2007), 17Mertens et al. (2004).