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. 2013 Dec 5;8:4659–4671. doi: 10.2147/IJN.S51927

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© 2013 Rangger et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Fluorescence microscopy images of different cell lines incubated with RhB-labeled liposomal nanoparticles. (A) Negative control cell line L-929 showed no binding of RhB-Hybrid-LPs. (B) M21 cells incubated with RhB-NoTarget-LP indicated no cellular interactions. (C) Image of M21 cells showing binding of RhB-RLP (yellow circles). (D) Image of U-87 MG cells showing cellular interactions with RhB-SP-LP (red circles).

Abbreviations: Hybrid-LP, liposomal nanoparticle carrying an RGD and SP building block; LP, liposome; NoTarget-LP, liposomal nanoparticle with no targeting sequence; RGD, arginine-glycine-aspartic acid; RhB, Rhodamine-B; RLP, liposomal nanoparticle carrying an RGD building block; SP, substance P.