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. 2013 Dec 5;8:4659–4671. doi: 10.2147/IJN.S51927

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© 2013 Rangger et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Representative MRI images of tumor-xenografted BALB/c nude mice before and after injection of Gd-RLP or Gd-NoTarget-LP (n=2). The increase in R1 over time is indicated as a change of color in the ROI. The U-87 MG tumor xenograft is labeled with a white circle. (A) Tumor uptake of Gd-RLP in the U-87 MG tumor xenograft at 2.5 hours post-injection. (B) For Gd-NoTarget-LP no significant uptake in the U-87 MG tumor xenograft could be observed within the 3-hour observation period.

Abbreviations: Gd, gadolinium; h, hour; LP, liposome; MRI, magnetic resonance imaging; NoTarget-LP, liposomal nanoparticle with no targeting sequence; pi, post-injection; RGD, arginine-glycine-aspartic acid; RLP, liposomal nanoparticle carrying an RGD building block; ROI, region of interest.