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. 2013 Dec 5;8:4659–4671. doi: 10.2147/IJN.S51927

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© 2013 Rangger et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Off-line analysis of the MRI images showing a significant uptake (increase of R1 over time) of Gd-RLP in the U-87 MG tumor xenograft within the observation period. For the M21 tumor xenograft an increase of R1 was observed only for the 2.5-hour image.

Note: Values are expressed as means ± standard deviation.Abbreviations: Gd, gadolinium; h, hour; MRI, magnetic resonance imaging; pi, post-injection; RGD, arginine-glycine-aspartic acid; RLP, liposomal nanoparticle carrying an RGD building block.