Table 1.

Composition of different liposomal formulations: molar ratios of the building blocks and targeting sequences

Liposome type	Cholesterol	POPC	DMPE-DTPA	DSPE-PEG(2000)	RGD	Substance P
RLP	2	3	0.3	0.3	0.3 (6 mol%)
SP-LP	2	3	0.3	0.3		0.3 (6 mol%)
Hybrid-LP	2	3	0.3	0.3	0.015 (0.3 mol%)	0.015 (0.3 mol%)
NoTarget-LP	2	3	0.3	0.3	–	–

Abbreviations: DMPE, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine; DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine; DTPA, diethylenetriaminepentaacetic acid; Hybrid-LP, liposomal nanoparticle carrying an RGD and SP building block; LP, liposome; NoTarget-LP, liposomal nanoparticle with no targeting sequence; PEG, polyethylene glycol; POPC, 1-palmitoyl-sn-glycero-3-phosphocholine; RGD, arginine-glycine-aspartic acid; RLP, liposomal nanoparticle carrying an RGD building block; SP, substance P; SP-LP, liposomal nanoparticle carrying an SP building block.