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. 2013 Dec 13;8(12):e82426. doi: 10.1371/journal.pone.0082426

Figure 4. Genetic alterations in the TP53 pathway in representative tumor cases.

Figure 4

(A) Representative DNA sequencing of TP53 mutations: TP53 mutation Y220C in case 383 with NBS1 mutation V348D, TP53 mutation P301L in case 217 with NBS1 mutation I41M. (B) MDM2 amplification in case 354 with NBS1 mutation S415R. The dopamine receptor (DR) sequence was used as the reference. (C) p14ARF homozygous deletion in case 217 with NBS1 mutation I41M. The GAPDH sequence was used as the reference. (D) p14ARF promoter methylation in case 425 with NBS1 mutation S638P. U: unmethylated; M: methylated; PC: methylated DNA (Zymo Research, Irvine, CA); NC: unmethylated DNA from normal blood; M: 50 bp DNA ladder.