Table 3. Association between genetic alterations in the TP53 pathway and NBS1 mutation in HCC and ICC.

	HCC (n=64)			ICC (n=18)			PLC* (n=82)
NBS1 mutation	Yes	No	P-valuea	Yes	No	P-valuea	Yes	No	P-valuea
TP53 mutation
Yes	2	7	0.1957	1	1	0.2157	3	8	0.0701
No	4	51		1	15		5	66
MDM2 amplification
Yes	1	3	0.3322	0	1	1.0000	1	4	0.4096
No	5	55		2	15		7	70
p14 homozygous deletion
Yes	1	5	1.0000	0	1	1.0000	1	6	1.0000
No	5	53		2	15		7	68
p14 promoter methylation
Yes	2	18	1.0000	2	3	0.0653	4	21	0.2389
No	4	40		0	13		4	53
At least one of the above four alterations
Yes	5	33	0.3875	2	5	0.1373	7	38	0.0672
No	1	25		0	11		1	36

^aFisher’s exact test. ^*PLC: primary liver cancer.