Table 3. Adjusted odds ratio (AOR) and 95% confidence intervals (CIs) of oral cancer associated with genotypic frequencies of IL-18 -607A/C and IL-18 -137G/C.
| Variable | Controls (n=559) (%) | Patients (n=567) (%) | AOR (95% CI) | p value |
|---|---|---|---|---|
| IL-18 -607 | ||||
| CC | 135 (24.1%) | 140 (24.7%) | 1.00 | |
| AC | 276 (49.4%) | 262 (46.2%) | 0.91 (0.62-1.34) | p=0.65 |
| AA | 148 (26.5%) | 165 (29.1%) | 1.04 (0.67-1.60) | p=0.84 |
| IL-18 -137 | ||||
| GG | 476 (85.2%) | 437 (77.1%) | 1.00 | |
| GC | 78 (13.9%) | 122 (21.5%) | 1.64 (1.08-2.48) | p=0.02 |
| CC | 5 (0.9%) | 8 (1.4%) | 0.89 (0.21-3.68) | p=0.88 |
| IL-18 genes combination | ||||
| Group 1 | 131 (23.4%) | 139 (24.5%) | 1.00 | |
| Group 2 | 349 (62.4%) | 299 (52.7%) | 0.81 (0.55-1.19) | p=0.29 |
| Group 3 | 79 (14.2%) | 129 (22.8%) | 1.43 (0.87-2.33) | p=0.15 |
The odds ratios (ORs) with their 95% confidence intervals (CIs) were estimated by logistic regression models.
The adjusted odds ratios (AORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression models, after controlling for gender, age, alcohol, tobacco, and areca consumption.
Group 1: individuals with CC of IL-18 -607 and GG of IL-18 -137; Group 2: individuals with at least one of the following, including A/C or A/A of IL-18 -607, or G/C or C/C of IL-18 -137; Group 3: individuals with A/C or A/A of IL-18 -607, and G/C or C/C of IL-18 -137.