Figure 1. Patient disposition.

Patients who completed the single treatment and repeated weekly dosing period were specified to have completed as scheduled. ^aA fourth patient was enrolled by mistake. ^bOne patient was treated with the wrong dose of study medication. ^cWithdrawal of consent. ^dDisease progression. ^eThe patient erroneously treated with wrong dose of study medication was withdrawn (same patient as in footnote b). ^fPatient went to primary care physician for further visits. ^gAdverse event. N=total number of patients; n=number of patients in the subgroup.