Table 4. IV doses (mg/kg) at which the average subject would be expected to reach TEVs.
Schedule
|
|||
---|---|---|---|
Weekly | Every 14 days | Every 21 days | |
Cmax | 2.3 | 3.3 | 3.8 |
Cmin | 1.7 | 5.1 | 10.8 |
AUC | 2.1 | 4.5 | 6.2 |
AUC, area under the plasma-concentration versus time curve; Cmax, maximum plasma concentration; Cmin, trough or minimum plasma concentration; IV, intravenous; TEVs, target exposure values.