Figure 3. Transferring B-lymphocytes leads to an asthma-like response after TDI challenge in B-KO and SCID BALB/c mice.

Airway methacholine reactivity was measured after transferring B-lymphocytes in B-KO (A) or SCID (F) mice. Macrophages and neutrophils were identified in the BAL fluid (B and G) and in lung tissue (D, E and H, I) 24 hours after the challenge. Total IgE was assessed in serum of B KO mice. Experimental groups for the adoptive transfer setup are identical to those of Figure 2 (DTDIRVeh and DTDIRTDI). Data are presented as means ± SEM, n = 5-8 per group, * p < 0.05, ** p < 0.01, *** p < 0.001 compared to the DTDIRVeh group. Symbols: (↑) inflammation and (▲) epithelial damage.