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. 2013 Dec 13;8(12):e84306. doi: 10.1371/journal.pone.0084306

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© 2013 Clifford, Kaplan

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Normal 184D, 184A1, and MCF10A cells and tumorous MCF10CA1, MCF7, and MDA-MB-231 cells were treated with (A) ouabain (B) bufalin, or (C) digitoxin for 24 hours, and viability was determined by PrestoBlue Viability assay. Normal cells exhibited a concentration-dependent decrease in viability when treated with all CTS compounds tested. Tumor MCF7 and MDA-MB-231 cells were more resistant to CTS-induced cell death than MCF10A cells. Level of significance was determined (p<0.05) using ANOVA for group comparisons or Student’s t-test for individual comparisons.