Table 3. ERK and Src inhibitors do not sensitize tumor cells to CTS-induced cell death.
Treatment | MCF7 | MDAMB231 |
---|---|---|
Control | 100 ± 3.04 | 100 ± 17.7 |
500 nM Ouabain | 89.56 ± 3.58 | 85.06 ± 12.69 |
5 µM ERK Inhibitor | 104.10 ± 0.26 | 103.66 ± 10.42 |
10 µM Src Inhibitor | 97.08 ± 2.26 | 86.60 ± 12.94 |
Ouabain + ERK Inhibitor | 83.69 ± 1.72 | 77.60 ± 9.51 |
Ouabain + Src Inhibitor | 81.14 ± 2.26 | 76.82 ± 12.15 |
Viability is displayed as the percentage of viable cells relative to untreated control; mean ± SE; n=3. Differences in viability from treatments with ouabain only compared to with ouabain plus inhibitor were not statistically significant (p>0.05).