Table 1. Infarct size, tissue weights and indoxyl sulfate levels.
| Sham (n = 13) | MI + Vehicle (n = 17) | MI + AST-120 (n = 14) | |
|---|---|---|---|
| Infarct size (%) | – | 41.6 | 43.8 |
| Body weight (g) | 546.7 ± 12.42 | 538.1 ± 12.35 | 521.4 ± 16.31 |
| Organ weight | |||
| HW/BW (g/kg) | 2.47 ± 0.06 | 2.74 ± 0.07** | 2.83 ± 0.10* |
| LV/BW (g/kg) | 1.77 ± 0.05 | 1.94 ± 0.06* | 2.03 ± 0.06* |
| Lung/BW (g/kg) | 2.87 ± 0.08 | 3.03 ± 0.06 | 3.10 ± 0.08 |
| Kidney/BW (g/kg) | 6.45 ± 0.18 | 6.76 ± 0.16 | 6.59 ± 0.15 |
| Serum indoxyl sulfate (mg/dL) | |||
| Week 0 (Baseline) | 0.10 ± 0.02 | 0.10 ± 0.01 | 0.10 ± 0.2 |
| Week 8 | 0.19 ± 0.02 | 0.21 ± 0.01 | 0.04 ± 0.004***,††† |
| Week 16 (Endpoint) | 0.19 ± 0.02 | 0.26 ± 0.03* | 0.03 ± 0.004***,††† |
| Change in serum indoxyl sulfate | |||
| (Endpoint - Baseline) (mg/dL) | 0.08 ± 0.01 | 0.17 ± 0.03* | -0.07 ± 0.02***,††† |
| 24-h urinary indoxyl sulfate (mg) | |||
| Week 8 | 3.6 ± 0.2 | 4.2 ± 0.2 | 0.8 ± 0.1***,††† |
| Week 16 | 4.4 ± 0.3 | 4.2 ± 0.3 | 0.8 ± 0.1***,††† |
Data are presented as mean ± SEM.
*p<0.05, **p<0.01, ***p<0.001 vs Sham. †††p<0.001 vs MI+Vehicle.
HW/BW - heart weight/body weight; LV/BW - left ventricular weight/body weight.