Table 1. The sEHI treatment reduced the proportion of mice experiencing tonic seizures but did not provide significant protection against clonic seizures.

compound (mg/kg)+pentylenetetrazole	mean§ time to clonic seizure in seconds (SEM)	protected from clonic/total	mean§ time to tonic seizure in seconds (SEM)	protected from tonic/total
Vehicle (PEG400)	257 (31)	0/12	425 (45)	0/12
TUPS (0.1)	308 (59)	0/14	799 (77)*	0/14
TUPS (0.3)	338 (54)	0/22	947 (94)*	7/22*
TUPS (1)	516 (102)	0/18	809 (95)*	8/18*
Diazepam (0.3)	192 (57)	0/8	633 (140)*	0/8
Diazepam (1)	404 (21)	4/8*	>1800	8/8*

Diazepam at a high dose was effective in protecting from both clonic and tonic seizures.

^§Mean values with animals protected from clonic or tonic seizures excluded.