Table 2. The effects of allopregnenolone was significantly enhanced by sEHI and partially antagonized by finasteride (One Way ANOVA followed by Student Newman Keuls post hoc analysis TUPS+Allo vs TUPS, *p = 0.016, TUPS+Allo vs Allo, **p = 0.007, TUPS vs TUPS+FIN, #p = 0.02).

compound (mg/kg)+pentylenetetrazole	mean time to clonic seizure in seconds (SEM)	mean time to tonic seizure in seconds (SEM)§	protected from tonic/total
Vehicle (PEG400)	257 (31)	425 (45)	0/12
TUPS (1)	516 (102)	809 (95)*	8/18
Finasteride (10)	204 (38)	619 (80)	0/8
TUPS+Finasteride (1+10)	185 (19)#	630 (66)	3/8
Allopregnenolone (1)	161 (24)	587 (145)**	0/4
Allopregnenolone (3)	397 (16)	850 (40)	1/4
TUPS+Allopregnenolone (1+1)	537 (113)	1663 (478)	3/4

Finasteride was administered 2 h, TUPS was administered 1 h, allopregnenolone, 10 min prior to PTZ.

^§Observation period was extended to 45 min to increase the dynamic range of the assay.