Table 1.
Characteristics of 322 patients from control group and 19 long-term survivors (patients surviving for at least 3 years with brain metastases).
| Characteristics (p-value) | Control group [number (%)]a | Long-term survivors [number (%)]a |
|---|---|---|
| Gender (p = 0.003) | ||
| Male | 232 (72) | 6 (32) |
| Female | 90 (28) | 13 (68) |
| Age (p = 0.16) | ||
| Median [range] | 59 [31–79] | 55 [42–71] |
| <65 years | 241 (75) | 15 (79) |
| ≥65 years | 81 (25) | 4 (21) |
| Histology | ||
| SCLC (p = 0.0004) | 132 (41) | 0 (0) |
| Squamous carcinoma | 67 (20) | 3 (11) |
| Adenocarcinoma (p < 0.00001) | 76 (24) | 15 (84) |
| Large cell carcinoma | 3 (1) | 0 (0) |
| NSCLC without type specification | 44 (14) | 1 (5) |
| RTOG/RPA prognostic class (p = 0.0001) | ||
| Class 1 | 41 (13) | 14 (75) |
| Class 2 | 215 (67) | 5 (25) |
| Class 3 | 66 (20) | 0 |
| KPS (p = 0.03) | ||
| >70 | 256 (80) | 19 (100) |
| ≤70 | 66 (20) | 0 |
| Presence of extracranial metastases (p = 0.01) | ||
| Yes | 83 (26) | 0 |
| No | 229 (71) | 19 (100) |
| Unknown | 10 (3) | 0 |
| Control of the primary tumor (p < 0.00001) | ||
| Yes | 88 (27) | 18 (95) |
| No | 222 (69) | 1 (5) |
| Unknown | 12 (4) | 0 |
| Number of BM (p = 0.00001) | ||
| Single | 124 (39) | 12(63) |
| Multiple | 190 (59) | 7(37) |
| Unknown | 8 (2) | 0 |
| Interval from diagnosis of the primary to development of BM (p = 0.44) | ||
| Synchronous | 147 (46) | 7(37) |
| Metachronous | 175 (54) | 12(63) |
| Surgery of BM (p = 0.00001) | ||
| Yes | 44 (14) | 10 (53) |
| No | 278 (86) | 9 (47) |
| Surgery in the treatment of the primary (p = 0.00001) | ||
| Yes | 30 (9) | 11 (58) |
| No | 292 (91) | 8 (42) |
a
Unless otherwise stated.