Table 2.

Randomized studies comparing short-course RT vs. long-course RT.

	BJS 2006 Polish study		JCO 2012 RTOG 01.04
	5 × 5 + TME	50.4/5FU bolus + TME	5 × 5 + TME 6 adjuvant CT	50.4/5-FU ci + TME 4 adjuvant CT
N	155	157	163	163
Follow-up	4 years		5.9 years
Local failure	9%	14.2%	7.5%	4.4%
DFS	58%	55%	73%	70%
OS	67%	62%	74%	70%
G3-G4 GI			3.2%	5.1%
G3-G4 Global	10.1%	7.1%	5.8%	8.2%

Ci, continuous infusion; DFS, disease-free survival; GI, gastrointestinal; OS, overall survival. p ≤ 0.05.