Table 5.
Results of randomized “boost versus no boost” trials.
| Clinical trial | Patient no. | Technique | Boost dose (Gy) | Median FUP (years) | 5-Year LR boost vs. no boost (%) | 10-Year LR boost vs. no boost (%) | p-Value |
|---|---|---|---|---|---|---|---|
| EORTC5 | 5318 | EBI/LDR BT | 15–16 | 10.8 | 4.3 vs. 7.3 | 6.2 vs. 10.2 | <0.0001 |
| HNIO4,6,7 | 627 | ELE/HDR BT | 12–16 | 5 | 6.3 vs. 13.3 | NR | 0.0017 |
| Lyon8 | 1024 | ELE | 10 | 3.3 | 3.6 vs. 4.5 | NR | 0.044 |
EORTC = European Organization for Research and Treatment of Cancer; HNIO = Hungarian National Institute of Oncology; FUP = follow-up period; LR = local recurrence; EBI = external beam irradiation (photons or electrons); ELE = electrons; LDR = low-dose-rate; HDR = high-dose-rate; BT = brachytherapy; NR = not reported.