. Author manuscript; available in PMC: 2013 Dec 14.

Published in final edited form as: Immunol Cell Biol. 2011 Jan 11;89(2):10.1038/icb.2010.158. doi: 10.1038/icb.2010.158

Table 1.

CXCR3 and its ligands

Receptor	Highly expressed	Ligands	Activity	Ligand inducers	Promoter elements
CXCR3	Effector CD4⁺Th1, CD8⁺CTL, NK and NKT cells, pDCs	CXCL9	Activate to induce chemotaxis, cell migration and adhesion	IFN-γ⋙TNF	γIRE-1, NF-κB2
		CXCL10		IFN-γ>IFN-α/β>TNF	IRSE, NF-κB1
		CXCL11		IFN-γ=IFN-β>IFN-α>TNF	STAT3, NF-κB2

Abbreviations: CTL, cytotoxic lymphocyte; DC, dendritic cell; IFN, interferon; NF, nuclear factor; NK, natural killer; NKT, natural killer T celI; Th1, type-1 helper; TNF, tumor necrosis factor.