Table 1.

Putative Functional Binding Partners of RACK1

Function	Protein	Score	Function	Protein	Score
Protein kinases	PRKCE	0.845	Cell motility/polarity/organization	PDE4D	0.845
	SRC	0.845		PTPRM	0.845
	PRKCA	0.619		STAT3	0.825
	PRKCB	0.619		INSR	0.824
	PRKCD	0.559		IGF1R	0.821
	PRKCQ	0.559		ITGB1	0.808
	PRKD1	0.559		TUBB2A	0.619
IFN/immune signaling	IFNAR2	0.911		DNM1	0.619
	STAT1	0.784		PLEC	0.619
	NSMAF	0.619		PLCG1	0.619
	CSF2RB	0.619		SERBP1	0.552
	SLC9A3R1	0.619		ITGB7	0.538
	IL2RB	0.569		ITGB2	0.530
	IL4R	0.569		ITGB5	0.530
	JAK1	0.569	Neuronal function/brain	FYN	0.845
	JAK3	0.569		GABRB3	0.619
	JAK2	0.569		SYT1	0.619
	TYK2	0.569		GRIN2B	0.619
	EPOR	0.569		SLC6A16	0.530
	IFNAR1	0.530		SLC6A3	0.530
Ribosome/translation	RPS13	0.837	Others	GNB1	0.619
	RPS5	0.813		AGTRAP	0.619
	HABP4	0.792		AR	0.619
	RPS20	0.673		RASA3	0.619
	EIF6	0.619		NFATC1	0.619
	LARP4B	0.619		RASA1	0.619
	PABPC1	0.619		SUMO4	0.619
	RPS3	0.554		SREK1	0.603
	RPS15	0.548		SAP25	0.591
Cell death/survival	TP63	0.809		LRP12	0.563
	TNFRSF1A	0.619		ST7	0.563
	TP73	0.555		OTUB1	0.562
	BCL2L11	0.538		GRAP2	0.543
	RB1	0.530		DLC1	0.538
Cell proliferation	ACHE	0.619		HIF1A	0.530
	CCNA1	0.562		SAT1	0.530

Note: Seventy-two binding partners with functional relevance were suggested using the String 9.0 database (http://string-db.org) (setting: threshold of 0.5; prediction mode: experiment; protein names and string score are listed). Proteins were manually sorted into putative functional clusters.