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. 2013 Dec 10;81(24):2121–2127. doi: 10.1212/01.wnl.0000437302.36064.b1

Figure 1. Semiacute and longitudinal group differences in FA.

Figure 1

(A) Regions showing increased fractional anisotropy (FA) for patients with mild traumatic brain injury (mTBI) relative to healthy controls (HCs) during the semiacute injury phase after correction for multiple comparison (α = 0.05). The magnitude of significance is denoted by color (red, corrected p < 0.05; yellow, p < 0.005), and data are presented for the right hemisphere (RH) and left hemisphere (LH). Regions included the left (Montreal Neurological Institute [MNI] coordinates = −16.5, 49.8, 27.3) and right (MNI coordinates = 12.3, 62.2, 15.8) superior frontal cortex. (B) Box-and-whisker plots used to denote the distribution of the FA within these regions for both patients with mTBI (red boxplots) and controls (blue boxplots). (C) Regions that exhibited a main effect of group in the FreeSurfer longitudinal pipeline analyses. Increased FA was again observed within the left (MNI coordinates = −16.3, 60.9, 6.5) superior frontal cortex for patients with mTBI. (D) Box-and-whisker plots used to denote the longitudinal changes in distribution of the FA within the left superior frontal cortex for returning patients with mTBI (n = 26; yellow boxplots) and matched controls (cyan boxplots) at both visits 1 (V1) and 2 (V2).