Table 1.
Disorder | N | Age | M:F | IHC | Diagnostic criteria | Regions studied |
---|---|---|---|---|---|---|
AD | 6 | 78 (9.2) | 3:3 | AT8 (tau) | NINCDS/ADRDA/CERAD | SFG, SPL, ITG, PHG VC |
PiD | 10 | 65.3 (11.3) | 7:3 | TP70 (tau) | Cairns et al. (2007) | SFG, ITG, PHG |
CBD | 12 | 64.7 (9.07) | 8:4 | TP007 (tau) | NIH-ORD | SFG, SPL, ITG, PHG |
PSP | 8 | 73.4 (7.4) | 4:4 | TP70 (tau) | NINDS-SPSP | SFG, ITG, PHG |
DLB | 12 | 73.8 (7.2) | 12:0 | α116 | CDLB (α-synuclein) | SFG, ITG, PHG |
MSA | 10 | 66.5 (8.51) | 7:3 | α116 | MCC (α-synuclein) | SFG, ITG, PHG |
NIFID | 10 | 45.3 (12.1) | 7:3 | FUS | Cairns et al. (2007) | SFG, ITG, PHG |
FTLD-TDP | 15 | 69.6 (8.50) | 7:2 | TDP-43 | Cairns et al. (2007) | SFG, ITG, PHG |
AD Alzheimer’s disease, PiD Pick’s disease, CBD corticobasal degeneration, PSP progressive supranuclear palsy, DLB dementia with Lewy bodies, MSA multiple system atrophy, NIFID neuronal intermediate filament inclusion disease, FTLD-TDP frontotemporal lobar degeneration with TDP-43 proteinopathy, FUS fused in sarcoma, TDP-43 transactive response (TAR) DNA-binding protein, N number of cases studied, IHC immunohistochemistry, M male, F female, SFG superior frontal gyrus (B8), SPL superior parietal lobule (B7a/7b), ITG inferior temporal gyrus (B22), PHG parahippocampal gyrus (B28), VC visual cortex (B17). Diagnostic criteria: ‘National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer Disease and Related Disorders Association’ (NINCDS/ADRDA) (Tierney et al. 1988), ‘Consortium to Establish a Registry of Alzheimer Disease’ (CERAD) criteria (Mirra et al. 1991); National Institute of Health-Office of rare disorders (NIH-ORD); National Institute of Neurological Disorders and Stroke (NINDS) and the Society of PSP (SPSP) (NINDS-SPSP) (Hauw et al. 1994, Litvan et al. 1996); ‘Consortium on Dementia with Lewy bodies’ (CDLB)’ (McKeith et al. 1996); ‘Minneapolis Consensus Criteria (MCC) (Gilman et al. 1998); Diagnostic criteria for PiD, NIFID and FTLD-TDP according to Cairns et al. (2007)