Table 3.
Number of variants and histopathological subtype of melanoma.
Analysis was performed separately by MM patient subtype. In the MPM subgroup only the first tumours were included in the analysis.
| Total MC1R Variants | |||||
|---|---|---|---|---|---|
| 0 (%) | 1 (%) | ≥2 (%) | Total (%) | P-value | |
| LMM | 57 (41.9) | 53 (39.0) | 26 (19.1) | 136 (100) | 0.028 |
| SSM | 503 (42.4) | 433 (35.5) | 251(21.1) | 1187 (100) | n.s. |
| NM | 122 (45.4) | 96 (35.7) | 51 (19) | 269 (100) | n.s. |
| ALM | 54 (62.1) | 23 (26.4) | 10 (11.5) | 87 (100) | n.s. |
|
| |||||
| Number or non Red hair colour variants | |||||
| 0 (%) | 1 (%) | ≥2 (%) | Total (%) | P-value | |
|
| |||||
| LMM | 82 (60.3) | 47 (34.6) | 7 (5.1) | 136 (100) | 0.382 |
| SSM | 698 (58.8) | 401 (33.8) | 88 (7.4) | 1187 (100) | n.s. |
| NM | 163 (60.0) | 87 (32.3) | 19(7.1) | 269 (100) | n.s. |
| ALM | 61 (70.1) | 19 (21.8) | 7 (8.0) | 87 (100) | n.s. |
|
| |||||
| Number Red hair colour variants | |||||
| 0 (%) | 1 (%) | ≥2 (%) | Total (%) | P-value | |
|
| |||||
| LMM | 98 (72.1) | 32 (23.5) | 6 (.4.4) | 136 (100) | 0.035 |
| SSM | 875 (73.7) | 264 (22.2) | 48 (4.0) | 1187 (100) | n.s. |
| NM | 199 (74.0) | 67 (24.9) | 3 (1.1) | 269 (100) | n.s. |
| ALM | 75 (86.2) | 11 (12.6) | 1 (1.1) | 87(100) | n.s. |
LMM: Lentigo maligna melanoma, SSM: Superficial spreading melanoma, NM: Nodular melanoma, ALM: Acral lentiginous melanoma.
n.s. not significant