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UNC-6-ligated UNC-40 induces a polarized distribution of UNC-40 in HSN (Xu et al., 2009). Genetic analyses indicate that UNC-6 induces UNC-40 polarization through parallel pathways comprising the cytoplasmic protein UNC-53 and the receptor UNC-5. The analyses also reveal an UNC-6-independent pathway that can induce the polarized UNC-40 distribution and which can be inhibited by UNC-53 activity.
