Fig. 1. Summary of the analyses performed.

This figure summarizes the analyses performed in this work, indicating the specific questions addressed and the datasets used. For each human protein-coding duplicated gene (PGD) we determined: (1) its duplication age, (2) whether it is within a CNV region in current human populations, and (3) its replication timing (RT) during S phase. We use this gene-centered information to investigate the involvement of CNVs in gene birth through duplication during human evolution and the possible influence of replication timing in these gene duplication events.